Atrophogenicity is the ability of a steroid to cause atrophy in the skin if used topically. Multiple methods can be used in order to measure atrophogenicity.
Animal studies:
- Inhibition of fibroblast growth in vitro
- Neutral red release assay
- Mouse tail epidermis
- Transgenic mouse model
- Guinea pig epidermis
Human studies:
- Micrometer callipers
- Histopathological examination of skin biopsies
- Radiography
- Pulsed ultrasound
