Atrophogenicity is the ability of a steroid to cause atrophy in the skin if used topically. Multiple methods can be used in order to measure atrophogenicity.

Animal studies:

  • Inhibition of fibroblast growth in vitro
  • Neutral red release assay
  • Mouse tail epidermis
  • Transgenic mouse model
  • Guinea pig epidermis

Human studies:

  • Micrometer callipers
  • Histopathological examination of skin biopsies
  • Radiography
  • Pulsed ultrasound