Differential Diagnosis in medicine is one of the most difficult things to perform, especially when some systemic diseases come across in the clinics. The Top 10 most difficult to diagnose diseases in medicine are as follows:

10. Heavy Metal Posioning

9. Celiac Disease

8. Infectious Diseases esp. syphillis, Lyme’s Disease, Nocardosis & Tuberculosis

7. Sarcodosis

6. Multiple Sclerosis

5. Fibromyalgia

4. Systemic Lupus erythematosus

3. Digestive Disorders

2. Psychiatric and Neurological Conditions

1. Neonatological Diseases